In time Oomoto came to have two headquarters: One at Ayabe (77 kilometers northwest of Kyoto), home of the Foundress, and one at Kameoka (23 kilometers west of Kyoto), birthplace of Onisaburo.

The Ayabe Headquarters, clustered around sacred Mt. Tsuruyama, is Oomoto´s "Spiritual Center".

The Kameoka Headquarters, built on the grounds of old Kameyama Castle, is Oomoto´s "Center of Activities".